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Amyloid and Related Disorders: Surgical Pathology and by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A.

By Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera

The moment version of this article provides an summary of the newest advancements during this zone together with scientific presentation, etiology, pathogenesis, and differential prognosis. the reason for varied treatments, together with transplantation, is mentioned and tissue prognosis (its pitfalls and techniques for fending off them) and laboratory help are incorporated. The involvement of all significant organ platforms together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central apprehensive approach, gentle tissue, pores and skin, lymph node/spleen and bone marrow pathology is additionally covered.

Amyloid and similar issues, moment Edition may be necessary to really expert and basic pathologists in addition to cytopathologists. different doctors can also take advantage of this concise replace at the systemic amyloidoses.

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Targeting unfolded protein response signaling pathways to Anti-amyloid antibodies 8. 9. 10. ameliorate protein misfolding diseases. Curr Opin Chem Biol. 2013;17:346–52. Westermark GT, Westermark P. Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis. FEBS Lett. 2009;583:2685–90. Corlin DB, Heegaard NH. Beta(2)-microglobulin amyloidosis. Subcell Biochem. 2012;65:517–40. Abrahamson M, Grubb A. Increased body temperature accelerates aggregation of the Leu-68→Gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy.

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